In a heart-wrenching scene that unfolded in a bustling city, a cry for help echoed through the streets—a plea for mercy from a scared and injured puppy, hidden away in a desperate attempt to shield himself from the world.
The call came to Animal Aid, an organization dedicated to the welfare of animals in distress. With urgency in their hearts, they mobilized their team and set out to rescue the frightened pup from the shadows of fear.
As they approached the scene of the distress, they were met with a sight that pierced their souls—a small, trembling figure cowering beneath a bag, his eyes wide with terror and pain. It was clear that this pup had been through unimaginable suffering, his body bearing the scars of neglect and abuse.
With gentle hands and soothing words, the rescuers sought to coax the pup out from his hiding place, offering reassurance and comfort in the face of his fear. But the pup remained wary, his instincts telling him to retreat further into the darkness.
Undeterred by the challenge before them, the rescuers employed a clever tactic—they used crackers, a simple yet effective lure to entice the pup out into the open. Slowly but surely, the scent of the treats proved irresistible, and with cautious steps, the pup emerged from his hiding spot, his eyes wary but curious.
With a mixture of relief and determination, the rescuers gently scooped up the pup, cradling him in their arms as they whisked him away to safety. And as they arrived at Animal Aid’s facilities, they knew that the journey was far from over—the pup would need extensive medical care and rehabilitation to heal his wounds, both physical and emotional.
But despite the challenges ahead, there was hope in their hearts—for the pup, and for all the animals like him who had been cast aside and forgotten by society. With each passing day, the pup grew stronger and more confident, his spirit buoyed by the love and support of those around him.
And today, thanks to the tireless efforts of Animal Aid and the unwavering kindness of strangers, the once scared and injured pup is thriving—a testament to the resilience of the canine spirit and the power of compassion to transform lives.
So here’s to Jumper, the brave little pup who dared to hope in the face of adversity, and to all the animals who have found solace and sanctuary in the arms of those who care. May their stories inspire us to be kinder, more compassionate beings, and may we never turn a blind eye to those in need.
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We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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