
When I noticed my wife drawing strange tally marks on her hand, I shrugged it off as a quirky habit. But as those marks multiplied and her answers remained cryptic, I realized something much darker was lurking beneath the surface of our seemingly happy marriage.
“Married life is great, right?” I would say to my friends when they asked. And for the most part, it was. We’d only been married for a few months, and I was still getting used to being a husband. My wife, Sarah, was always so organized, so thoughtful. She had a way of making everything seem effortless.
But then, something changed. I started noticing a strange habit of hers. One day, she pulled a pen out of her purse and made a small tally mark on the back of her hand. I didn’t think much of it at first.
“Did you just mark your hand?” I asked, raising an eyebrow.
She smiled and shrugged. “Just a reminder.”
“A reminder for what?” I laughed, thinking it was a joke. But she didn’t answer. She just changed the subject.
Over the next few weeks, she did it more and more. Some days, there’d be only one or two marks. Other days, five or more. Then there’d be days with nothing at all. It seemed random, but it bothered me. What was she keeping track of?
The more I noticed, the more I started to worry. It was like she was keeping a secret from me, and that secret was slowly eating away at our happiness.
One night, I couldn’t hold it in any longer.
“Sarah, what’s with the tally marks?” I asked as we were getting ready for bed. “You do it all the time now.”
She glanced at the marks on her hand, then looked at me with that same mysterious smile. “It helps me remember things, that’s all.”
“Remember what?” I pressed.
“It’s just… things,” she said, brushing me off like it was nothing. “Don’t worry about it.”
But I did worry. A lot. I started paying closer attention. She’d mark her hand after dinner. After we argued. After we watched a movie. There was no pattern I could see.
One evening, I counted the marks on her hand: seven. That night, I watched as she transferred them into a small notebook by her bedside table. She didn’t know I was watching.
I decided to check her notebook the next morning. I waited until she was in the shower, then flipped through the pages. Each page had rows and rows of tally marks. I counted them—68 in total.
I sat on the bed, staring at the notebook in my hands. What did this number mean? What was she counting?
I tried asking her again a few days later.
“Sarah, please tell me what those marks are for. It’s driving me crazy.”
She sighed, clearly annoyed. “I told you. It’s just something I do. It helps me remember.”
“That doesn’t make any sense!” I snapped. “What are you remembering? Are you keeping track of something? Someone?”
“Just drop it, okay?” she said, her voice sharp. She looked at me, her eyes pleading. “Please, just let it go.”
But I couldn’t let it go. The marks started to feel like a wall between us. Every time I saw her make a new one, it was like she was putting up another brick, shutting me out.
I became obsessed with the number 68. What was so important about it? I noticed I was being more careful around her, almost like I was afraid to give her a reason to add another mark. But then the marks would still appear, no matter what I did.
One night, after another tense conversation, I watched her add four new marks to her hand. I needed to know what was happening. I needed to figure this out before it drove me mad. But I had no idea how to get the truth out of her. And that scared me more than anything.
I couldn’t shake the feeling that our entire marriage was on the line, and I was helpless to stop whatever was happening between us. I left for several days to see if it changed anything. Well, the tally count has increased to 78 by the time I returned.
The obsession with Sarah’s tally marks was eating me alive. I needed a break from it, but everywhere I looked, I saw her hand with those little black lines, like they were taunting me. So, when Sarah suggested we visit her mother, I thought it would be a good distraction.
Her mother, Diane, and her fifth husband, Jake, lived in a cozy house in the suburbs. It was a typical Saturday afternoon visit: tea, cookies, and small talk. Sarah and her mom were in the kitchen, chatting and laughing. I excused myself to use the bathroom.
As I passed by the guest bedroom, something caught my eye. There, on the nightstand, was a notebook. It looked just like the one Sarah kept by her bed. I hesitated, but curiosity got the better of me. I stepped inside, glancing over my shoulder to make sure no one was watching.
I opened the notebook, my hands trembling. Inside, there were pages filled with tally marks, just like Sarah’s. But there was more. Next to the marks were labels: “interrupting,” “raising voice,” “forgetting to call.” Each tally had a label, like it was keeping track of mistakes.
“What the hell is this?” I muttered under my breath.
I felt a chill run down my spine. Was this some kind of family tradition? Was Sarah’s mom counting her own mistakes? Were they both holding themselves to these impossible standards?
I closed the notebook and returned to the living room, trying to act normal, but my mind was spinning. Sarah noticed my unease.
“You okay?” she asked, concern in her eyes.
“Yeah, I’m fine,” I lied. “Just thinking about work.”
We stayed for another hour, but I was barely present. My thoughts kept drifting back to that.
On the drive home, I couldn’t hold it in anymore.
“Sarah, I need to ask you something,” I said, gripping the steering wheel.
She looked at me, puzzled. “What’s up?”
“I saw your mom’s notebook today. It looked a lot like yours. Is this something you both do? Are you counting your mistakes? You don’t have to be perfect, you know. You don’t need to keep track of every little thing.”
There was a moment of silence, then she let out a bitter laugh.
“You think I’m counting my mistakes?”
“Well, yeah,” I said, relieved she was finally opening up. “You shouldn’t be so hard on yourself. It’s okay to mess up sometimes.”
She shook her head, staring out the window. “I’m not counting my mistakes, Jack. I’m counting yours.”
The words hit me like a punch in the gut. “What?”
“Every time you break one of your vows, I make a mark,” she said quietly. “When you interrupt me, when you don’t listen, when you say you’ll do something and don’t. I’ve been keeping track since our wedding.”
On our wedding day, I promised Sarah the world in my vows. I vowed never to lie, to always listen without interrupting, and to be there every time she needed me, no matter what. It was a long list of grand, heartfelt promises that sounded perfect in the moment, but looking back, they were almost impossible to keep.
I felt the blood drain from my face. “You’re counting my mistakes? Why?”
“Because I want to know when I’ve had enough,” she said, her voice breaking. “When you reach 1,000 marks, I’m leaving.”
I pulled the car over, my heart pounding. “You’re going to leave me? For breaking some stupid promises?”
“They’re not stupid promises,” she snapped. “They’re our wedding vows, Jack. You made them to me, and you’ve broken every single one.”
I stared at her, stunned. How had we gotten here? How had I missed this? I’d thought she was being hard on herself, but I was the one who’d been careless, dismissive. I wanted to be angry, but I couldn’t. I was too shocked, too hurt.
When we got home, I couldn’t sleep. I called Diane, desperate for answers.
“Sarah told me what she’s doing,” I said. “Why didn’t you stop her?”
Diane sighed. “I did the same thing with my past husbands. I thought it would help, but it just drove us apart. It ruined my marriages.”
“Then why let her—”
“I tried to tell her,” she interrupted gently. “But she needs to see it for herself. I count good days now, Jack. Good things my husband does. It changed everything.”
I hung up, feeling more lost than ever. I could only hope that my mother-in-law’s words fell on fertile ground.
That evening, Sarah came home with tears in her eyes. “I’m so sorry,” she whispered, wrapping her arms around me. “I didn’t realize how much this was hurting us.”
I held her close, feeling a mix of relief and hope. “Let’s forget the tally marks,” I said softly. “Let’s start fresh.”
The next day, I bought a new notebook—one for us to fill with good memories and happy moments. We made our first entry that night, writing about a quiet dinner we shared, laughing and talking like we hadn’t in months.
As we moved forward, the notebook became a symbol of our promise to focus on the positives and grow together. The tally marks were gone, replaced by stories of joy, love, and gratitude. We were finally on the same page, and it felt like the beginning of something beautiful.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.

On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.

Fully regrown frontal teeth in ferrets
The next steps

Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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